A Simple Theory of Motor Protein
نویسنده
چکیده
A three-state stochastic model of motor protein Qian, Biophys. Chem., (1997)] is further developed to illustrate the relationship between the external load on an individual motor protein in aqueous solution with various ATP concentration and its steady-state velocity. A wide variety of dynamic motor behavior are obtained from this simple model. For the particular case of free-load translocation being the most unfavorable step within the hydrolysis cycle, the load-velocity curve is quasi-linear, v=v max = (c F=Fmax ? c)=(1 ? c), in contrast to the hyperbolic relationship proposed by A.V. Hill for macroscopic muscle. Signiicant deviation from the linearity is expected when the velocity is less than 10% of its maximal (free load) value-a situation under which the processivity of motor diminishes and experimental observations are less certain. We then investigate the dependence of load-velocity curve on ATP (ADP) concentration. It is shown that the free load v max exhibits a Michaelis-Menten like behavior, and the isometric F max increases linearly with ln((ATP]//ADP]). However, the quasi-linear region is independent of the ATP concentration, yielding an apparently ATP-independent maximal force below the true isometric force. Finally, the heat production as function of ATP concentration and external load are calculated. In simple terms and solved with elementary algebra, the present model provides an integrated picture of biochemical kinetics and mechanical energetics of motor proteins.
منابع مشابه
Modified Couple Stress Theory for Vibration of Embedded Bioliquid-Filled Microtubules under Walking a Motor Protein Including Surface Effects
Microtubules (MTs) are fibrous and tube-like cell substructures exist in cytoplasm of cells which play a vital role in many cellular processes. Surface effects on the vibration of bioliquid MTs surrounded by cytoplasm is investigated in this study. The emphasis is placed on the effect of the motor protein motion on the MTs. The MT is modeled as an orthotropic beam and the surrounded cytoplasm i...
متن کاملRobust Control of Encoderless Synchronous Reluctance Motor Drives Based on Adaptive Backstepping and Input-Output Feedback Linearization Techniques
In this paper, the design and implementation of adaptive speed controller for a sensorless synchronous reluctance motor (SynRM) drive system is proposed. A combination of well-known adaptive input-output feedback linearization (AIOFL) and adaptive backstepping (ABS) techniques are used for speed tracking control of SynRM. The AIOFL controller is capable of estimating motor two-axis inductances ...
متن کاملa Simple Speed Control Technique and Pulsating Torque Elimination Method in a Brushless Dc Motor
This paper presents a theoretical derivation and computer simulation of an optimal speed controller for a brushless dc motor using feedback from a linear model running in parallel with the inverter-fed model. The intent of the feedback from the linear model is to eliminate torque ripples from the inverter drive. A nonlinear model of such a motor, transformed into a linear model by a local diphe...
متن کاملSpinal Muscular Atrophy: A Short Review Article
Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein level reduces in patients with SMA. Two different genes code survival motor neuron protein in human genome. Skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...
متن کاملThe effects of bile duct ligation on motor cortex region morphology and aquaporin 4 protein concentration in male Wistar rats
Impaired motor functions were reported in cholestatic animals. This disorder in the function and death of motor neurons is highly dependent on changes in the environment around astrocytes and the blood-brain barrier, which is moderated by the aquaporin 4 protein. For this reason, the effects of cholestasis on motor cortex histology and morphology and aquaporin 4 protein levels were investigated...
متن کاملPredicting working Memory (Visual-Spatial) Based on Motor Skills and Self-Regulation from the perspective of Barkly theory in Dysgraphia Children 8-12 Years old
Introduction: Children with dysgraphia have some problems with motor skills and self-regulation. The aim of this study was to predict working memory (visual-spatial) based on motor skills and self-regulation from the perspective of Barkley's theory in children with dysgraphia aged 8-12 years old. Methods: This study was a correlational study. The study sample consisted of 150 male students who ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 1999